I carry a 3.8 at 7-8 o'clock (left handed) with full forward cant and also carry my wallet in my left back pocket. The biggest issue i find is that the barrel on my 3.8 ends only an inch or two from the top of my back pocket, making pulling my wallet out slightly awkward (I definitely won't be getting pick-pocketed lol), which I've gotten used to now, but I'd imagine with a 4.5 it'd be almost impossible to carry it where I do right now and keep my wallet in the same pocket (where I've been carrying my wallet since I was a kid, that's not going to change lol).