Being of the pleasantly plump persuasion myself(6'2" 325), I found that I needed to add another piece of leather to go between the grip and my side. My pistol grip was biting into my skin otherwise. Just something to keep in mind.
I'm 5'10 and 260, I Carry a full framed XDm in a Kholster comfortably. They are inexpensive and the guy that owns the company is awesome. Highly recommended if you don't have the spare $ for the crossbreed. Also keep in mind you will want a gun belt, which inexpensive ones run 30$.
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