It'll work with anything from a little .22, up to fast DA with a .44 magnum.
I ain't Leatham, and Springfield don't build me trick guns or provide me with thousands of rounds of target loads to burn up every year. I have to teach cops to save their lives with a handgun (as in "one hand if necessary").
Some of them have done just that, and thanked me profusely after the dust had settled. The last one mentioned that he was very glad that I had rode him until he learned to use his Glock with one hand- because when his personal "ballon went up" there was no time for anything else.
I recommend that you do not adopt any shooting method or stance that detracts from your ability to use the gun effectively, with one hand, in an emergency. Using your strong-hand thumb for anything besides hanging onto the gun is developing bad, possibly fatal habits.
I guess I forgot we were talking about shooting targets instead of saving our bacon, here.