Nope. By itself it's fine shooting a RH tavor left-handed, no issues (for me) when used normally (read: non-silenced).
Silenced is a different matter altogether - I don't shoot my Tavor silenced normally (just slapped the can on for the pic), as it's too uncomfortable with all burning gases shootings to my eyes/face. They creep up from under my eyepro, it's quite nauseating. I'd recommend if using a can is your intent, then you should send it to IWI to get it converted to LH config. I may send mine in eventually, but I tend to use that can only on my SCAR 17 so it's been a non-issue.
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