My new 45 shoots about 4" low and 2" to the left. I haven't tried any factory ammo, but I've tried 4 different 200gr loads and 4 different 230gr loads. So far I've tried Unique, HS-6, and Bluedot, these are the powders I have on hand. Bullets have been Berry 200gr HP, and RAiner 230gr HP. Any suggestions are appreciated.