I have a 22-45, too but its a pretty reliable beast and only misfeeds on cheapo ammo or when its really filthy. I am a huge fan of the 22-45 and have shot one for around 10 years. Mine gets quite a workout with my wife and daughter blazing away with it all the time! LOL
It is ONLY doing this on the first round out of a fully loaded mag?
When it jams, is it failing to go into battery and only halfway closed with the round mostly in the chamber or is it hung on the feedramp at an angle? I ask, because both FTF and failure to go into battery can be caused by different things.
If its failing to go into battery, you might need a stronger recoil spring in the pistol. No problemmo...Wolff makes them and they're cheap. Worth a try. I'd also swap the springs in the magazines. It is possible that they can come from the factory on the weak side.
I'd also check the chamber and make very sure that you have it cleaned out really well and that there is not some sort of fouling that has built up where the chamber engages the rifling. Sometimes, with filthy lead ammo, you can get fouling there that is hard to see, but is just enough to cause rounds to not seat all the way in the chamber and cause failures to go into battery.
Good luck...sounds like a small and fixable problem.
Carp Diem - fish all day
Es mejor morir a pie que vivir arrodillad